Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons

Highlights ► Menthol raised thresholds of dorsal horn neuronal responses to noxious heat. ► Low-concentration menthol enhanced cold-evoked responses and reduced threshold. ► High-concentration menthol reduced cold-evoked responses and increased threshold. ► Menthol did not affect mechanosensitivity....

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Bibliographic Details
Published in:Neuroscience 2012-09, Vol.219, p.234-242
Main Authors: Klein, A.H, Sawyer, C.M, Takechi, K, Davoodi, A, Ivanov, M.A, Carstens, M.I, Carstens, E
Format: Article
Language:English
Subjects:
Administration, Topical
Analgesics - pharmacology
Animals
Biological and medical sciences
cold hyperalgesia
Cold Temperature
dorsal horn neurons
Fundamental and applied biological sciences. Psychology
heat analgesia
Hindlimb
Hot Temperature
L-menthol
Lumbosacral Region
Male
Medical sciences
Menthol - pharmacology
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Pain Threshold - drug effects
Posterior Horn Cells - drug effects
Rats
Rats, Sprague-Dawley
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Menthol raised thresholds of dorsal horn neuronal responses to noxious heat. ► Low-concentration menthol enhanced cold-evoked responses and reduced threshold. ► High-concentration menthol reduced cold-evoked responses and increased threshold. ► Menthol did not affect mechanosensitivity.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.05.061