A New Histone at the Centromere?

The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore comp...

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Bibliographic Details
Published in:Cell 2012-02, Vol.148 (3), p.394-396
Main Authors: Foltz, Daniel R., Stukenberg, P. Todd
Format: Article
Language:English
Subjects:
chromatin
epigenetics
functional properties
histones
kinetochores
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Summary:The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional properties with canonical histones.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2012.01.023