Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring

A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), wer...

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Bibliographic Details
Published in:Tetrahedron letters 2012-08, Vol.53 (32), p.4202-4205
Main Authors: Gerea, Alexandra L., Branscum, Katie M., King, Jarrod B., You, Jianlan, Powell, Douglas R., Miller, Andrew N., Spear, John R., Cichewicz, Robert H.
Format: Article
Language:English
Subjects:
Biofilm
Fungi
Microbial mat
Secondary metabolites
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Summary:A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possibly Entrophospora sp.) and a Dothideomycete (possibly Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A–E (5, 6, 10–12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.05.156