Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cyt...

Full description

Saved in:
Bibliographic Details
Published in:Iranian red crescent medical journal 2011, Vol.13 (1), p.52-54
Main Authors: Karimi, M., Muslimi, S., Sarikhani, S., Cohan, N.
Format: Article
Language:English
Subjects:
Bones
Case Report
Diseases
Lymphoblastic leukemia
Osteoporosis
ابيضاض الدم الليمفاوي الحاد
الأمراض
العظام
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease
ISSN:2074-1804
2074-1812