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Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cyt...
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| Published in: | Iranian red crescent medical journal 2011, Vol.13 (1), p.52-54 |
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| Language: | English |
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| container_end_page | 54 |
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| container_title | Iranian red crescent medical journal |
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| creator | Karimi, M. Muslimi, S. Sarikhani, S. Cohan, N. |
| description | Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have
been described in association with ALL including osteoprosis and bone fractures. Different factors including the
disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate,
corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic
conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to
recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse
effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the
disease |
| format | article |
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been described in association with ALL including osteoprosis and bone fractures. Different factors including the
disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate,
corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic
conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to
recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse
effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the
disease</description><identifier>ISSN: 2074-1804</identifier><identifier>EISSN: 2074-1812</identifier><identifier>PMID: 22946019</identifier><language>eng</language><publisher>Dubai, United Arab Emirates: Iranian Hospital</publisher><subject>Bones ; Case Report ; Diseases ; Lymphoblastic leukemia ; Osteoporosis ; ابيضاض الدم الليمفاوي الحاد ; الأمراض ; العظام</subject><ispartof>Iranian red crescent medical journal, 2011, Vol.13 (1), p.52-54</ispartof><rights>Copyright Dr Ali Akbari Sari, Director of The Commission for Accreditation & Improvement of Iranian Medical Journals Jan 2011</rights><rights>Copyright © 2011, Kowsar Corp. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407586/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407586/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22946019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karimi, M.</creatorcontrib><creatorcontrib>Muslimi, S.</creatorcontrib><creatorcontrib>Sarikhani, S.</creatorcontrib><creatorcontrib>Cohan, N.</creatorcontrib><title>Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures</title><title>Iranian red crescent medical journal</title><addtitle>Iran Red Crescent Med J</addtitle><description>Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have
been described in association with ALL including osteoprosis and bone fractures. Different factors including the
disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate,
corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic
conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to
recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse
effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the
disease</description><subject>Bones</subject><subject>Case Report</subject><subject>Diseases</subject><subject>Lymphoblastic leukemia</subject><subject>Osteoporosis</subject><subject>ابيضاض الدم الليمفاوي الحاد</subject><subject>الأمراض</subject><subject>العظام</subject><issn>2074-1804</issn><issn>2074-1812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpVkFlLAzEQgBdRbK3-BCX4vpBrrxdBikeh4Is-L9nsxKZmkzWH0n_vQuv1NMPMxzfHUTanuOI5qQk9_skxn2VnIWwxLpqSstNsRmnDS0yaeWZXVkctDBo9BLBRRO0scgoJmSIgsxvGjeuMCFFLZCC9waAF-tRxg1yI4EbnXdABCdujIZmoRwMojG4yWXApoM5ZQMoLGdM04Tw7UcIEuDjERfZyf_e8fMzXTw-r5e06B1rTmBPVd8Ar1TeEq6KUDZakLkTNKZcF4YRxRUjRNT1hCmOQDUjG-7IjCnPGKGGL7GbvHVM3QC-ny7ww7ej1IPyudUK3_ztWb9pX99EyjquiLifB9UHg3XuCENutS95OO7d1UTWUEFZP0NXfKT_67_dOwOUegKkOSvwSBcW4Zl8ejYUO</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Karimi, M.</creator><creator>Muslimi, S.</creator><creator>Sarikhani, S.</creator><creator>Cohan, N.</creator><general>Iranian Hospital</general><general>Zamen Salamati Publishing</general><general>Kowsar</general><scope>AACQA</scope><scope>ADJCN</scope><scope>AEION</scope><scope>AHFXO</scope><scope>AHHHR</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>2011</creationdate><title>Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures</title><author>Karimi, M. ; 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Skeletal abnormalities have
been described in association with ALL including osteoprosis and bone fractures. Different factors including the
disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate,
corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic
conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to
recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse
effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the
disease</abstract><cop>Dubai, United Arab Emirates</cop><pub>Iranian Hospital</pub><pmid>22946019</pmid><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2074-1804 |
| ispartof | Iranian red crescent medical journal, 2011, Vol.13 (1), p.52-54 |
| issn | 2074-1804 2074-1812 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3407586 |
| source | PubMed Central(OpenAccess) |
| subjects | Bones Case Report Diseases Lymphoblastic leukemia Osteoporosis ابيضاض الدم الليمفاوي الحاد الأمراض العظام |
| title | Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures |
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