Effects of cold air on cardiovascular disease risk factors in rat

The purpose of this study is to explore possible potential implications of cold air in cardiovascular disease (CVD) risk in rats. Healthy Wistar rats were exposed to artificial cold air under laboratory conditions, and their systolic blood pressure, heart rate, vasoconstriction, CVD risk factors, an...

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Bibliographic Details
Published in:International journal of environmental research and public health 2012-07, Vol.9 (7), p.2312-2325
Main Authors: Luo, Bin, Zhang, Shuyu, Ma, Shoucun, Zhou, Ji, Wang, Baojian
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Blood Viscosity
Body Weight
Cardiovascular disease
Cardiovascular Diseases - etiology
Cold
Cold Temperature - adverse effects
Fibrinogen - metabolism
Heart Rate
Lipids - blood
Male
Myocardium - pathology
Myoglobin - blood
Rats
Rats, Wistar
Risk Factors
Studies
Troponin T - blood
Vasoconstrictor Agents
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Summary:The purpose of this study is to explore possible potential implications of cold air in cardiovascular disease (CVD) risk in rats. Healthy Wistar rats were exposed to artificial cold air under laboratory conditions, and their systolic blood pressure, heart rate, vasoconstriction, CVD risk factors, and myocardial damage indicators after cold air exposure were determined and evaluated. Systolic blood pressure, whole blood viscosity, and plasma level of norepinephrine, angiotensinâ…ˇ, low density lipoprotein, total cholesterol, and fibrinogen in treatment groups increased significantly compared with control groups. No significant variations were found in plasma Mb and cTnT and myocardial tissue between the treatment and control groups. Results indicate that: (1) higher levels of SBP, WBV and LDL/HDL, total cholesterol (TC), and FG in blood may indicate higher CVD risks during cold air exposure; (2) cold air may exert continuous impacts on SBP and other CVD risk factors.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph9072312