MiR-210 – micromanager of the hypoxia pathway

Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upre...

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Bibliographic Details
Published in:Trends in molecular medicine 2010-05, Vol.16 (5), p.230-237
Main Authors: Huang, Xin, Le, Quynh-Thu, Giaccia, Amato J
Format: Article
Language:English
Subjects:
Animals
Humans
Hypoxia - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Biological
Pathology
Signal Transduction - genetics
Signal Transduction - physiology
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Summary:Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2010.03.004