MiR-210 – micromanager of the hypoxia pathway

Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upre...

Full description

Saved in:
Bibliographic Details
Published in:Trends in molecular medicine 2010-05, Vol.16 (5), p.230-237
Main Authors: Huang, Xin, Le, Quynh-Thu, Giaccia, Amato J
Format: Article
Language:English
Subjects:
Animals
Humans
Hypoxia - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Biological
Pathology
Signal Transduction - genetics
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203
cites cdi_FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203
container_end_page 237
container_issue 5
container_start_page 230
container_title Trends in molecular medicine
container_volume 16
creator Huang, Xin
Le, Quynh-Thu
Giaccia, Amato J
description Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.
doi_str_mv 10.1016/j.molmed.2010.03.004
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3408219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S147149141000047X</els_id><sourcerecordid>733527382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxi1ERUvhDRDKjVO24z-J4wsSqgpFKkJqQept5HUmXS9JvNjZwt76DrwhT4JXWxbKBV9s2TPf-Pt9jL3gMOPA65PlbAj9QO1MQL4COQNQj9gRV5qXypjrx_szV4fsaUpLAF5p3TxhhwKUVKZSR-zkg78sBYfi592PYvAuhsGO9oZiEbpiWlCx2KzCd2-LlZ0W3-zmGTvobJ_o-f1-zD6_Pft0el5efHz3_vTNRekqrqey65qqNU1NmnQnTa3JVM4prlpbWWXUnCswQErY1oAwTtbSqVrMNc21dQLkMXu9012t59mko3GKtsdV9IONGwzW48OX0S_wJtyiVNAIbrLAq3uBGL6uKU04-OSo7-1IYZ1QS1kJLRuRK9WuMptPKVK3n8IBt6hxiTvUuEWNIDGjzm0v__7hvuk32z8WKHO69RQxOU-jo9ZHchO2wf9vwr8Crvejd7b_QhtKy7COY84AOSaBgFfbuLdpc8hL6Wv5CwIPpnI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733527382</pqid></control><display><type>article</type><title>MiR-210 – micromanager of the hypoxia pathway</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Huang, Xin ; Le, Quynh-Thu ; Giaccia, Amato J</creator><creatorcontrib>Huang, Xin ; Le, Quynh-Thu ; Giaccia, Amato J</creatorcontrib><description>Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.</description><identifier>ISSN: 1471-4914</identifier><identifier>EISSN: 1471-499X</identifier><identifier>DOI: 10.1016/j.molmed.2010.03.004</identifier><identifier>PMID: 20434954</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Humans ; Hypoxia - genetics ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Models, Biological ; Pathology ; Signal Transduction - genetics ; Signal Transduction - physiology</subject><ispartof>Trends in molecular medicine, 2010-05, Vol.16 (5), p.230-237</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><rights>2010 Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203</citedby><cites>FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20434954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Xin</creatorcontrib><creatorcontrib>Le, Quynh-Thu</creatorcontrib><creatorcontrib>Giaccia, Amato J</creatorcontrib><title>MiR-210 – micromanager of the hypoxia pathway</title><title>Trends in molecular medicine</title><addtitle>Trends Mol Med</addtitle><description>Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.</description><subject>Animals</subject><subject>Humans</subject><subject>Hypoxia - genetics</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Models, Biological</subject><subject>Pathology</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><issn>1471-4914</issn><issn>1471-499X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQxi1ERUvhDRDKjVO24z-J4wsSqgpFKkJqQept5HUmXS9JvNjZwt76DrwhT4JXWxbKBV9s2TPf-Pt9jL3gMOPA65PlbAj9QO1MQL4COQNQj9gRV5qXypjrx_szV4fsaUpLAF5p3TxhhwKUVKZSR-zkg78sBYfi592PYvAuhsGO9oZiEbpiWlCx2KzCd2-LlZ0W3-zmGTvobJ_o-f1-zD6_Pft0el5efHz3_vTNRekqrqey65qqNU1NmnQnTa3JVM4prlpbWWXUnCswQErY1oAwTtbSqVrMNc21dQLkMXu9012t59mko3GKtsdV9IONGwzW48OX0S_wJtyiVNAIbrLAq3uBGL6uKU04-OSo7-1IYZ1QS1kJLRuRK9WuMptPKVK3n8IBt6hxiTvUuEWNIDGjzm0v__7hvuk32z8WKHO69RQxOU-jo9ZHchO2wf9vwr8Crvejd7b_QhtKy7COY84AOSaBgFfbuLdpc8hL6Wv5CwIPpnI</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Huang, Xin</creator><creator>Le, Quynh-Thu</creator><creator>Giaccia, Amato J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100501</creationdate><title>MiR-210 – micromanager of the hypoxia pathway</title><author>Huang, Xin ; Le, Quynh-Thu ; Giaccia, Amato J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Hypoxia - genetics</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Models, Biological</topic><topic>Pathology</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Xin</creatorcontrib><creatorcontrib>Le, Quynh-Thu</creatorcontrib><creatorcontrib>Giaccia, Amato J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Xin</au><au>Le, Quynh-Thu</au><au>Giaccia, Amato J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-210 – micromanager of the hypoxia pathway</atitle><jtitle>Trends in molecular medicine</jtitle><addtitle>Trends Mol Med</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>16</volume><issue>5</issue><spage>230</spage><epage>237</epage><pages>230-237</pages><issn>1471-4914</issn><eissn>1471-499X</eissn><abstract>Hypoxia inducible factors (HIFs) regulate a variety of genes to prepare cells to adapt and survive under a hypoxic environment. Recently, microRNAs (miRNAs) have emerged as a new class of genes regulated by HIFs in response to hypoxia, of which miR-210 is the most consistently and predominantly upregulated miRNA. Functional studies have demonstrated that miR-210 is a versatile gene that regulates many aspects of hypoxia pathways, both in physiological and malignant conditions. Here, we summarize recent findings on the mechanism of hypoxia regulation of miR-210 expression and its multifaceted biological functions in normal physiological and malignant conditions, and discuss the challenges we face in elucidating the biological functions of miR-210 and exploring its potential use for therapeutics.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20434954</pmid><doi>10.1016/j.molmed.2010.03.004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1471-4914
ispartof Trends in molecular medicine, 2010-05, Vol.16 (5), p.230-237
issn 1471-4914
1471-499X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3408219
source ScienceDirect Freedom Collection 2022-2024
subjects Animals
Humans
Hypoxia - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Biological
Pathology
Signal Transduction - genetics
Signal Transduction - physiology
title MiR-210 – micromanager of the hypoxia pathway
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-22T03%3A55%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MiR-210%20%E2%80%93%20micromanager%20of%20the%20hypoxia%20pathway&rft.jtitle=Trends%20in%20molecular%20medicine&rft.au=Huang,%20Xin&rft.date=2010-05-01&rft.volume=16&rft.issue=5&rft.spage=230&rft.epage=237&rft.pages=230-237&rft.issn=1471-4914&rft.eissn=1471-499X&rft_id=info:doi/10.1016/j.molmed.2010.03.004&rft_dat=%3Cproquest_pubme%3E733527382%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c517t-ff85d986e7e7f3967e95cc414da5a494b14090e42ad9029c363c462b7eb7ac203%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733527382&rft_id=info:pmid/20434954&rfr_iscdi=true