Clocks, Metabolism, and the Epigenome

Many behaviors and physiological activities in living organisms display circadian rhythms, allowing the organisms to anticipate and prepare for the diurnal changes in the living environment. In this way, metabolic processes are aligned with the periodic environmental changes and behavioral cycles, s...

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Bibliographic Details
Published in:Molecular cell 2012-07, Vol.47 (2), p.158-167
Main Authors: Feng, Dan, Lazar, Mitchell A.
Format: Article
Language:English
Subjects:
Animals
behavior change
biochemical pathways
Cell Nucleus - metabolism
Circadian Rhythm
Cytoplasm - metabolism
diurnal variation
energy metabolism
Epigenomics
fasting
Gene Expression Regulation
Glucose - metabolism
Heme - chemistry
Histones - metabolism
Homeostasis
Humans
Lipids - chemistry
Liver - metabolism
metabolic diseases
Models, Biological
organisms
Risk
sleep
transcription (genetics)
Transcription, Genetic
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Description
Summary:Many behaviors and physiological activities in living organisms display circadian rhythms, allowing the organisms to anticipate and prepare for the diurnal changes in the living environment. In this way, metabolic processes are aligned with the periodic environmental changes and behavioral cycles, such as the sleep/wake and fasting/feeding cycles. Disturbances of this alignment significantly increase the risk of metabolic diseases. Meanwhile, the circadian clock receives signals from the environment and feedback from metabolic pathways, and adjusts its activity and function. Growing evidence connects the circadian clock with epigenomic regulators. Here we review the recent advances in understanding the crosstalk between the circadian clock and energy metabolism through epigenomic programming and transcriptional regulation.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2012.06.026