Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy

• Published in: Epilepsy & behavior 2012-08, Vol.24 (4), p.399-402
• Main Authors: Talnov, Arkadij N, Isaeva, Elena, Savotchenko, Alina V, Dovgalets, Galina V, Ochoa, Juan G, Holmes, Gregory L, Isaev, Dmytro
• Format: Article
• Language: English
• Subjects: Absences WAG/Rij; Analysis of Variance; Animal models; Animals; Anticonvulsants - therapeutic use; Antiepileptic agents; Brain Waves - drug effects; Dietary; Disease Models, Animal; Electroencephalography; Electrolytes; Electrolytes - therapeutic use; Epilepsy; Epilepsy, Absence - drug therapy; Epilepsy, Absence - physiopathology; Genetic models of absence epilepsy; Hydration; Hyperosmolarity; Male; Neurology; osmolarity; Osmotic pressure; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Spike-and-wave
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2012.05.018

Abstract Although antiepileptic drugs are often effective in the control of seizures, some patients show little or no improvement. As alternative treatments, different dietary modifications were shown to be beneficial for patients with poor tolerance for AEDS. Previous reports have shown that rice-based oral electrolyte hydration therapy is effective in seizure control in patients with refractory absence seizures. In the present study, using an animal model of absence epilepsy, we showed that the occurrence of spike-and-wave discharges significantly decreases upon switching to electrolyte therapy. We also showed that consumption of solution with the same osmolarity as rice-based oral electrolyte solution leads to a decrease in the number of spike-and-wave discharges per hour. We suggest that the antiepileptic effect of rice-based oral electrolyte hydration therapy can be at least in part due to hyperosmolarity of the ingested solution.