Evaluation of a Second-Generation Self-Expanding Variable-Porosity Flow Diverter in a Rabbit Elastase Aneurysm Model

The self-expanding V-POD is a second-generation flow-diverting device with a low-porosity PTFE patch on a self-expanding microstent. The authors evaluated this device for the treatment of elastase-induced aneurysms in rabbits. Three V-POD types (A, circumferential patch closed-cell stent [n = 9]; B,...

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Published in:American journal of neuroradiology : AJNR 2011-09, Vol.32 (8), p.1399-1407
Main Authors: IONITA, C. N, NATARAJAN, S. K, WANG, W, HOPKINS, L. N, LEVY, E. I, SIDDIQUI, A. H, BEDNAREK, D. R, RUDIN, S
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Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular system
Disease Models, Animal
Equipment Design
Interventional
Intracranial Aneurysm - chemically induced
Intracranial Aneurysm - surgery
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Pancreatic Elastase - administration & dosage
Porosity
Rabbits
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stents
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creator IONITA, C. N
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LEVY, E. I
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BEDNAREK, D. R
RUDIN, S
description The self-expanding V-POD is a second-generation flow-diverting device with a low-porosity PTFE patch on a self-expanding microstent. The authors evaluated this device for the treatment of elastase-induced aneurysms in rabbits. Three V-POD types (A, circumferential patch closed-cell stent [n = 9]; B, asymmetric patch closed-cell stent [n = 7]; and C, asymmetric patch open-cell stent [n = 4]) were evaluated by using angiography, conebeam micro-CT, histology, and SEM. Aneurysm flow modifications were expressed in terms of immediate poststent/prestent ratios of maximum CA volume entering the aneurysm dome tracked on procedural angiograms. Flow modifications were correlated with 4 weeks' follow-up angiographic, micro-CT, histologic, and SEM results. Mechanical stent-deployment difficulties in 4 aneurysms (1 type A; 3 type B) led to suboptimal results and exclusion from analysis. Of the remaining 16 aneurysms, 4-week post-treatment angiograms showed no aneurysm filling in 10 (63%), 3 (∼19%) had no filling with a small remnant neck, and 3 (∼19%) had
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subjects Animals
Biological and medical sciences
Cardiovascular system
Disease Models, Animal
Equipment Design
Interventional
Intracranial Aneurysm - chemically induced
Intracranial Aneurysm - surgery
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Pancreatic Elastase - administration & dosage
Porosity
Rabbits
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stents
title Evaluation of a Second-Generation Self-Expanding Variable-Porosity Flow Diverter in a Rabbit Elastase Aneurysm Model
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