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Laboratory evaluation of primary immunodeficiencies
Primary immunodeficiencies are congenital disorders caused by defects in different elements of the immune system. Affected patients usually present clinically with recurrent infections, severe infections, or both, as well as autoimmune phenomena that are associated with many of these disorders. Earl...
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| Published in: | Journal of allergy and clinical immunology 2010-02, Vol.125 (2), p.S297-S305 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c537t-5b9bbfdadedea7638a758d096c6b1573ca2d3a0ca25a6cd771d1b2d39aa3322c3 |
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| cites | cdi_FETCH-LOGICAL-c537t-5b9bbfdadedea7638a758d096c6b1573ca2d3a0ca25a6cd771d1b2d39aa3322c3 |
| container_end_page | S305 |
| container_issue | 2 |
| container_start_page | S297 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 125 |
| creator | Oliveira, João B., MD, PhD Fleisher, Thomas A., MD |
| description | Primary immunodeficiencies are congenital disorders caused by defects in different elements of the immune system. Affected patients usually present clinically with recurrent infections, severe infections, or both, as well as autoimmune phenomena that are associated with many of these disorders. Early diagnosis is essential for referral to specialized care centers and the prompt initiation of appropriate therapy. In this article the authors describe a general approach for the investigation of the most common primary immunodeficiencies, outlining the typical clinical symptoms and most appropriate laboratory investigations. |
| doi_str_mv | 10.1016/j.jaci.2009.08.043 |
| format | article |
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Affected patients usually present clinically with recurrent infections, severe infections, or both, as well as autoimmune phenomena that are associated with many of these disorders. Early diagnosis is essential for referral to specialized care centers and the prompt initiation of appropriate therapy. 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| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2010-02, Vol.125 (2), p.S297-S305 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3412511 |
| source | ScienceDirect Journals |
| subjects | Allergy and Immunology Autoimmune Diseases - diagnosis Autoimmune Diseases - etiology Bacterial infections Clinical Laboratory Techniques Confidence intervals Cytokines Defects Dehydrogenases Ear diseases Early Diagnosis Flow cytometry Genetic Counseling Genotype & phenotype Humans Immune system immunity Immunity - genetics Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - diagnosis Immunologic Deficiency Syndromes - physiopathology immunologic diagnosis Infection - diagnosis Infection - etiology Kinases laboratory assessment Ligands Medical History Taking Patients Primary immunodeficiency Proteins Streptococcus infections Testing laboratories |
| title | Laboratory evaluation of primary immunodeficiencies |
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