Chromatin alterations in response to forced swimming underlie increased prodynorphin transcription

Highlights ► Forced swim stress induces region specific rise in dynorphin mRNA in caudate putamen. ► MeCP2 binding to CRE site in dynorphin gene promoter is correspondingly reduced. ► Phospho-CREB binding to select dynorphin gene promoter CRE sites is increased. ► Select histone modifications demons...

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Bibliographic Details
Published in:Neuroscience 2012-09, Vol.220, p.109-118
Main Authors: Reed, B, Fang, N, Mayer-Blackwell, B, Chen, S, Yuferov, V, Zhou, Y, Kreek, M.J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caudate Nucleus - metabolism
caudate putamen
Chromatin - genetics
Chromatin Immunoprecipitation
CREB
dynorphin
Enkephalins - biosynthesis
Enkephalins - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
histones
Male
MeCP2
Neurology
Protein Precursors - biosynthesis
Protein Precursors - genetics
Rats
Rats, Sprague-Dawley
Real-Time Polymerase Chain Reaction
stress
Stress, Psychological - genetics
Transcription, Genetic
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Forced swim stress induces region specific rise in dynorphin mRNA in caudate putamen. ► MeCP2 binding to CRE site in dynorphin gene promoter is correspondingly reduced. ► Phospho-CREB binding to select dynorphin gene promoter CRE sites is increased. ► Select histone modifications demonstrate reduced binding to dynorphin gene promoter.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.06.006