Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study

Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic resonance phase images. It is commonly assumed that paramagnetic iron is the predominant source of susceptibility variat...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2012-09, Vol.62 (3), p.1593-1599
Main Authors: Langkammer, Christian, Schweser, Ferdinand, Krebs, Nikolaus, Deistung, Andreas, Goessler, Walter, Scheurer, Eva, Sommer, Karsten, Reishofer, Gernot, Yen, Kathrin, Fazekas, Franz, Ropele, Stefan, Reichenbach, Jürgen R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alzheimer's disease
Autopsy
Brain
Brain Chemistry
Brain iron
Brain Mapping - methods
Brain research
Female
Humans
Image Interpretation, Computer-Assisted
Iron
Iron - analysis
Magnetic Resonance Imaging - methods
Male
Medical research
Middle Aged
Myelin
Phase imaging
Post mortem
Quantitative susceptibility mapping
Spectrophotometry, Atomic
Standard deviation
Studies
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Summary:Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic resonance phase images. It is commonly assumed that paramagnetic iron is the predominant source of susceptibility variations in gray matter as many studies have reported a reasonable correlation of magnetic susceptibility with brain iron concentrations in vivo. Instead of performing direct comparisons, however, all these studies used the putative iron concentrations reported in the hallmark study by Hallgren and Sourander (1958) for their analysis. Consequently, the extent to which QSM can serve to reliably assess brain iron levels is not yet fully clear. To provide such information we investigated the relation between bulk tissue magnetic susceptibility and brain iron concentration in unfixed (in situ) post mortem brains of 13 subjects using MRI and inductively coupled plasma mass spectrometry. A strong linear correlation between chemically determined iron concentration and bulk magnetic susceptibility was found in gray matter structures (r=0.84, p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2012.05.049