Review of the efficacy and safety of remifentanil for the prevention and treatment of pain during and after procedures and surgery

Remifentanil is an ultrashort-acting synthetic opioid. It is metabolized by nonspecific tissue and plasma esterases. Remifentanil's metabolism is responsible for its unique pharmacokinetic profile and flat, context-sensitive half-time. Since its introduction into clinical practice, remifentanil...

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Published in:Local and regional anesthesia 2010-01, Vol.3, p.35-43
Main Authors: Sivak, Erica L, Davis, Peter J
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description Remifentanil is an ultrashort-acting synthetic opioid. It is metabolized by nonspecific tissue and plasma esterases. Remifentanil's metabolism is responsible for its unique pharmacokinetic profile and flat, context-sensitive half-time. Since its introduction into clinical practice, remifentanil has been used for a variety of anesthetic and analgesic applications; however, concerns regarding a potential for rapid induction of tolerance and/or induced hyperalgesia, coupled with an ultrarapid offset of effect, make the drug less than optimal for use in the pharmacologic management of pain.
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title Review of the efficacy and safety of remifentanil for the prevention and treatment of pain during and after procedures and surgery
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