Nanofiber-based delivery of bioactive agents and stem cells to bone sites

Biodegradable nanofibers are important scaffolding materials for bone regeneration. In this paper, the basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed. In additi...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2012-09, Vol.64 (12), p.1129-1141
Main Authors: Zhang, Zhanpeng, Hu, Jiang, Ma, Peter X.
Format: Article
Language:English
Subjects:
Animals
Bioactive agent delivery
Bone and Bones - metabolism
Bone Regeneration
Bone tissue engineering
Bones
Drug Delivery Systems
Humans
Nanocomposites
Nanofibers - chemistry
Nanofibrous scaffold
Nanomaterials
Nanostructure
Osteogenic microenvironment
Regeneration
Scaffolds
Self assembly
Stem cell delivery
Stem Cell Transplantation - methods
Stem cells
Stem Cells - metabolism
Tissue Engineering
Tissue Scaffolds - chemistry
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Summary:Biodegradable nanofibers are important scaffolding materials for bone regeneration. In this paper, the basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed. In addition, surface functionalization and bioactive factor delivery within these nanofibrous scaffolds to enhance bone regeneration are also discussed. Moreover, recent progresses in applying these nanofiber-based scaffolds to deliver stem cells for bone regeneration are presented. Along with the significant advances, challenges and obstacles in the field as well as the future perspective are discussed. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.04.008