The existence of DNA sequences homologous to adenovirus 5 DNA in the genome of normal rat cells

Three discrete bands specifically hybridizing to adeno— virus 5 MA were found in the rat liver DNA restricted by Bam HI endonuclease and fractionated electrophoretically. The hybridization with different regions of the viral genome takes place. Similar bands are present in the DNA from different lin...

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Bibliographic Details
Published in:Nucleic acids research 1979-11, Vol.7 (6), p.1419-1428
Main Authors: Frolova, E.I., Georgiev, G.P.
Format: Article
Language:English
Subjects:
Adenoviridae - analysis
Adenovirus
Animals
Base Sequence
Cell Line
Cell Transformation, Viral
DNA
DNA Restriction Enzymes
DNA, Viral
Embryo, Mammalian
Nucleic Acid Hybridization
Rats
Species Specificity
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Summary:Three discrete bands specifically hybridizing to adeno— virus 5 MA were found in the rat liver DNA restricted by Bam HI endonuclease and fractionated electrophoretically. The hybridization with different regions of the viral genome takes place. Similar bands are present in the DNA from different lines of adenovirus 5 transformed cells, but in these cases high molecular weight DNA fragments containing the integrated viral genomes can also be found.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/7.6.1419