T cell tolerance and immunity to commensal bacteria

Highlights ► Tolerance is required to commensal bacteria and depends on regulatory T cells. ► Regulatory T cells specific to commensal bacteria are generated from naïve T cells in the periphery. ► Bacterial products can facilitate Treg cell function via the induction of IL-10, an immunosuppressive c...

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Bibliographic Details
Published in:Current opinion in immunology 2012-08, Vol.24 (4), p.385-391
Main Authors: Nutsch, Katherine M, Hsieh, Chyi-Song
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Autoimmunity
Cytokines - metabolism
Host-Pathogen Interactions
Humans
Immune Tolerance - immunology
Immunity, Mucosal - immunology
Intestinal Mucosa - microbiology
T-Lymphocytes, Regulatory - physiology
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Summary:Highlights ► Tolerance is required to commensal bacteria and depends on regulatory T cells. ► Regulatory T cells specific to commensal bacteria are generated from naïve T cells in the periphery. ► Bacterial products can facilitate Treg cell function via the induction of IL-10, an immunosuppressive cytokine. ► Specific commensal bacterial species induce inflammatory or tolerogenic T cell responses in the gut.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2012.04.009