p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2011-11, Vol.21 (8), p.224-228
Main Authors: Su, Huabo, Wang, Xuejun
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Autophagy
Cardiomyocytes
Cardiovascular
Heart Diseases - enzymology
Heart Diseases - pathology
Homeostasis
Humans
Ischemia
Mutation
Myocardium - enzymology
Myocardium - pathology
Pathogenesis
Proteasome Endopeptidase Complex - metabolism
Protein Folding
Proteins
Proteostasis Deficiencies - enzymology
Proteostasis Deficiencies - pathology
Quality control
Sequestosome-1 Protein
Signal Transduction
Stress, Physiological
Ubiquitin - metabolism
Up-Regulation
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Summary:As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2012.05.015