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p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in...

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Published in:	Trends in cardiovascular medicine 2011-11, Vol.21 (8), p.224-228
Main Authors:	Su, Huabo, Wang, Xuejun
Format:	Article
Language:	English
Subjects:	Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy Cardiomyocytes Cardiovascular Heart Diseases - enzymology Heart Diseases - pathology Homeostasis Humans Ischemia Mutation Myocardium - enzymology Myocardium - pathology Pathogenesis Proteasome Endopeptidase Complex - metabolism Protein Folding Proteins Proteostasis Deficiencies - enzymology Proteostasis Deficiencies - pathology Quality control Sequestosome-1 Protein Signal Transduction Stress, Physiological Ubiquitin - metabolism Up-Regulation
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description	As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.
doi_str_mv	10.1016/j.tcm.2012.05.015
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source	ScienceDirect Freedom Collection
subjects	Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy Cardiomyocytes Cardiovascular Heart Diseases - enzymology Heart Diseases - pathology Homeostasis Humans Ischemia Mutation Myocardium - enzymology Myocardium - pathology Pathogenesis Proteasome Endopeptidase Complex - metabolism Protein Folding Proteins Proteostasis Deficiencies - enzymology Proteostasis Deficiencies - pathology Quality control Sequestosome-1 Protein Signal Transduction Stress, Physiological Ubiquitin - metabolism Up-Regulation
title	p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress
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