Endocytosis and control of Notch signaling

The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and certain cancers. Studies over the last sever...

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Bibliographic Details
Published in:Current opinion in cell biology 2012-08, Vol.24 (4), p.534-540
Main Authors: Kandachar, Vasundhara, Roegiers, Fabrice
Format: Article
Language:English
Subjects:
Animals
Asymmetric Cell Division
Drosophila melanogaster - cytology
Drosophila melanogaster - metabolism
Drosophila Proteins - metabolism
Endocytosis
Humans
Internal Medicine
Juvenile Hormones - metabolism
Ligands
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Protein Transport
Receptors, Notch - metabolism
Signal Transduction
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Summary:The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and certain cancers. Studies over the last several years have revealed sophisticated regulation of both the membrane-bound Notch receptor and its ligands by vesicle trafficking. This is perhaps most evident in neural progenitor cells in Drosophila , which divide asymmetrically to segregate Numb, an endocytic adaptor protein that acts as a Notch pathway inhibitor, to one daughter cell. Here, we discuss recent findings addressing how receptor and ligand trafficking to specific membrane compartments control activation of the Notch pathway in asymmetrically dividing cells and other tissues.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2012.06.006