Challenging Regional Psoriasis and Ustekinumab Biotherapy : Impact of the Patterns of Disease

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and T...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Hermanns-Lê, Trinh, Berardesca, Enzo, Piérard, Gérald E., Lesuisse, Marianne, Piérard-Franchimont, Claudine
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Biological Therapy
Biomedical research
Case reports
Dermatologie
Dermatology
Disease
Drug therapy
Human health sciences
Humans
Light therapy
Organ Specificity
Psoriasis
Psoriasis - drug therapy
Psoriasis - pathology
Review
Sciences de la santé humaine
Ustekinumab
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Summary:In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.
ISSN:1110-7243
2314-6133
1110-7251
1110-7251
2314-6141
DOI:10.1155/2012/413767