The Spike-Timing Dependence of Plasticity

In spike-timing-dependent plasticity (STDP), the order and precise temporal interval between presynaptic and postsynaptic spikes determine the sign and magnitude of long-term potentiation (LTP) or depression (LTD). STDP is widely utilized in models of circuit-level plasticity, development, and learn...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2012-08, Vol.75 (4), p.556-571
Main Author: Feldman, Daniel E.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Brain
Cooperativity
Dendrites - physiology
Dependence
Humans
Mammals
Models, Neurological
Neural networks
Neuronal Plasticity - physiology
Neurons - cytology
Neurons - physiology
Neurotransmitter Agents - metabolism
Synapses - physiology
Time Factors
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Summary:In spike-timing-dependent plasticity (STDP), the order and precise temporal interval between presynaptic and postsynaptic spikes determine the sign and magnitude of long-term potentiation (LTP) or depression (LTD). STDP is widely utilized in models of circuit-level plasticity, development, and learning. However, spike timing is just one of several factors (including firing rate, synaptic cooperativity, and depolarization) that govern plasticity induction, and its relative importance varies across synapses and activity regimes. This review summarizes this broader view of plasticity, including the forms and cellular mechanisms for the spike-timing dependence of plasticity, and, the evidence that spike timing is an important determinant of plasticity in vivo. Spike-timing-dependent plasticity (STDP) is one of several factors critical for synaptic plasticity induction. In this review, Daniel Feldman describes and discusses the forms, cellular mechanisms, and significance of STDP in plasticity, development, and learning.
ISSN:0896-6273
1097-4199
1097-4199
DOI:10.1016/j.neuron.2012.08.001