The Influence of Cell Cycle Phase on ADC in Synchronized Cells Detected Using Temporal Diffusion Spectroscopy

The relationship between the apparent diffusion coefficient (ADC) of tissue water measured by magnetic resonance methods and the physiological status of cells is of particular relevance for better understanding and interpretation of diffusion-weighted MRI. In addition, there is considerable interest...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2010-11, Vol.65 (4), p.920-926
Main Authors: Xu, Junzhong, Xie, Jingping, Jourquin, Jerome, Colvin, Daniel C., Does, Mark D., Quaranta, Vito, Gore, John C.
Format: Article
Language:English
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Summary:The relationship between the apparent diffusion coefficient (ADC) of tissue water measured by magnetic resonance methods and the physiological status of cells is of particular relevance for better understanding and interpretation of diffusion-weighted MRI. In addition, there is considerable interest in developing diffusion-dependent imaging methods capable of providing novel information on tissue microstructure, including intracellular changes. To this end, both the conventional pulsed gradient spin echo (PGSE) methods and the oscillating gradient spin echo (OGSE) method, which probes diffusion over very short distance (
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.22704