Comparative Histomorphological Review of Rat and Human Hepatocellular Proliferative Lesions

In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2012, Vol.25(3), pp.189-199
Main Authors: Thoolen, Bob, Kate, Fiebo J.W. ten, Diest, Paul J. van, Malarkey, David E., Elmore, Susan A., Maronpot, Robert R.
Format: Article
Language:English
Subjects:
foci of cellular alteration
hepatocellular adenoma
hepatocellular carcinoma
Indexing in process
large cell change
liver
Review
small cell change
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Summary:In this comparative review, histomorphological features of common nonneoplastic and neoplastic hepatocyte lesions of rats and humans are examined using H&E-stained slides. The morphological similarities and differences of both neoplastic (hepatocellular carcinoma and hepatocellular adenoma) and presumptive preneoplastic lesions (large and small cell change in humans and foci of cellular alteration in rats) are presented and discussed. There are major similarities in the diagnostic features, growth patterns and behavior of both rat and human hepatocellular proliferative lesions and in the process of hepatocarcinogenesis. Further study of presumptive preneoplastic lesions in humans and rats should help to further define their role in progression to hepatocellular neoplasia in both species.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.25.189