Phylogenetic analysis of dengue virus types 1 and 4 circulating in Puerto Rico and Key West, Florida, during 2010 epidemics

We describe sequences of six strains of dengue virus (DENV): three DENV-1 isolates and two DENV-4 isolates from Puerto Rico, and a DENV-1 strain from Key West, Florida, obtained from blood donors during 2010 epidemics. Phylogenetic analysis revealed that the Puerto Rico DENV-1 strains constitute a n...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2012-09, Vol.87 (3), p.548-553
Main Authors: Añez, Germán, Heisey, Daniel A R, Espina, Luz M, Stramer, Susan L, Rios, Maria
Format: Article
Language:English
Subjects:
Dengue - epidemiology
Dengue - virology
Dengue virus
Dengue Virus - classification
Dengue Virus - genetics
Dengue Virus - isolation & purification
Epidemics
Florida - epidemiology
Genotype
Humans
Phylogeny
Puerto Rico - epidemiology
Sequence Analysis, DNA
Short Report
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Summary:We describe sequences of six strains of dengue virus (DENV): three DENV-1 isolates and two DENV-4 isolates from Puerto Rico, and a DENV-1 strain from Key West, Florida, obtained from blood donors during 2010 epidemics. Phylogenetic analysis revealed that the Puerto Rico DENV-1 strains constitute a new lineage within genotype V different from those that circulated in Puerto Rico during the past two decades. The newer Puerto Rico DENV-1 strains associated with strains from the Caribbean and South America. The DENV-1 strain from Key West, Florida clustered with a strain isolated from mosquito pools collected in that area and with a number of strains from Nicaragua and Mexico circulating during 2006-2009. The Puerto Rico DENV-4 isolates of genotype II associated with strains that have circulated on the island throughout the 1980s and 1990s and with strains from the Caribbean region and Central America. Introduction and circulation of novel DENV lineages in dengue-endemic regions have the potential to increase the severity of dengue cases.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2012.12-0091