New Approaches to Genetic Counseling and Testing for Alzheimer’s Disease and Frontotemporal Degeneration

The discovery of new autosomal dominant and susceptibility genes for Alzheimer’s disease (AD) and frontotemporal degeneration (FTD) is revealing important new information about the neurodegenerative process and the risk for acquiring these diseases. It is becoming increasingly clear that both the me...

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Bibliographic Details
Published in:Current neurology and neuroscience reports 2012-10, Vol.12 (5), p.502-510
Main Author: Goldman, Jill S.
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer's disease
Chromosomes
Cognitive ability
Dementia
Dementia (KS Marder
Disease
Frontal Lobe - metabolism
Frontal Lobe - pathology
Genes
Genetic counseling
Genetic Counseling - methods
Genetic Predisposition to Disease
Genetic testing
Genetic Testing - methods
Genetics
Genomes
Humans
Medicine
Medicine & Public Health
Mutation
Neurology
Neurosciences
Section Editor
Temporal Lobe - metabolism
Temporal Lobe - pathology
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Description
Summary:The discovery of new autosomal dominant and susceptibility genes for Alzheimer’s disease (AD) and frontotemporal degeneration (FTD) is revealing important new information about the neurodegenerative process and the risk for acquiring these diseases. It is becoming increasingly clear that both the mechanisms that drive these diseases and their phenotypes overlap. New technologies will assist access to genetic testing but may increase difficulty with genetic test interpretation. Thus, the process of genetic counseling and testing for these diseases is becoming more complex. This article will review current knowledge on the genetics of AD and FTD and suggest clinical guidelines for helping families to navigate through these complexities. The implications of future discoveries will be offered.
ISSN:1528-4042
1534-6293
DOI:10.1007/s11910-012-0296-1