Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD

Summary Background Conventional magnetic resonance imaging (MRI) techniques that measure hepatic steatosis are limited by T1 bias, T2* decay and multi‐frequency signal‐interference effects of protons in fat. Newer MR techniques such as the proton density‐fat fraction (PDFF) that correct for these fa...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2012-07, Vol.36 (1), p.22-29
Main Authors: Permutt, Z., Le, T.-A., Peterson, M. R., Seki, E., Brenner, D. A., Sirlin, C., Loomba, R.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Cohort Studies
Cross-Sectional Studies
Digestive system
Fatty Liver - diagnosis
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver - pathology
Liver Cirrhosis - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Non-alcoholic Fatty Liver Disease
Other diseases. Semiology
Pharmacology. Drug treatments
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
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Summary:Summary Background Conventional magnetic resonance imaging (MRI) techniques that measure hepatic steatosis are limited by T1 bias, T2* decay and multi‐frequency signal‐interference effects of protons in fat. Newer MR techniques such as the proton density‐fat fraction (PDFF) that correct for these factors have not been specifically compared to liver biopsy in adult patients with non‐alcoholic fatty liver disease (NAFLD). Aim To examine the association between MRI‐determined PDFF and histology‐determined steatosis grade, and their association with fibrosis. Methods A total of 51 adult patients with biopsy‐confirmed NAFLD underwent metabolic‐biochemical profiling, MRI‐determined PDFF measurement of hepatic steatosis and liver biopsy assessment according to NASH‐CRN histological scoring system. Results The average MRI‐determined PDFF increased significantly with increasing histology‐determined steatosis grade: 8.9% at grade‐1, 16.3% at grade‐2, and 25.0% at grade‐3 with P ≤ 0.0001 (correlation: r2 = 0.56, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2012.05121.x