Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women

Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. The s...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2012-10, Vol.67 (10), p.1092-1098
Main Authors: Slinin, Yelena, Paudel, Misti, Taylor, Brent C, Ishani, Areef, Rossom, Rebecca, Yaffe, Kristine, Blackwell, Terri, Lui, Li-Yung, Hochberg, Marc, Ensrud, Kristine E
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - blood
Aging - psychology
Cognition
Cognition & reasoning
Cognition Disorders - blood
Cognition Disorders - etiology
Cohort Studies
Cross-Sectional Studies
Executive Function
Female
Gerontology
Humans
Longitudinal Studies
Mental health
Odds Ratio
Older people
Prospective Studies
Risk Factors
United States
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Women
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Summary:Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. The study is a cross-sectional and longitudinal analysis of a prospective cohort of 6,257 community-dwelling elderly women followed for 4 years. Global cognitive function was measured by the Modified Mini-Mental State Examination and executive function was measured by Trail Making Test Part B (Trails B). Cognitive impairment at baseline was defined as a score >1.5 SD below the sample mean; cognitive decline was defined as decline from baseline to follow-up >1 SD from mean change in score. Women with very low vitamin D levels had an increased odds of global cognitive impairment at baseline: odds ratio (95% confidence interval), 1.60 (1.05-2.42) for women with 25(OH)D
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/gls075