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Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort

Previously we reported that airborne concentrations of cis-permethrin, but not trans-permethrin, measured during pregnancy in an inner city pediatric cohort was associated with cough by age 5. However, the effect of subsequent exposures to both permethrins during early childhood, and to piperonyl bu...

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Bibliographic Details
Published in:Environment international 2012-11, Vol.48, p.156-161
Main Authors: Liu, Bian, Jung, Kyung Hwa, Horton, Megan K., Camann, David E., Liu, Xinhua, Reardon, Ann Marie, Perzanowski, Matthew S., Zhang, Hanjie, Perera, Frederica P., Whyatt, Robin M., Miller, Rachel L.
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Language:English
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Summary:Previously we reported that airborne concentrations of cis-permethrin, but not trans-permethrin, measured during pregnancy in an inner city pediatric cohort was associated with cough by age 5. However, the effect of subsequent exposures to both permethrins during early childhood, and to piperonyl butoxide (PBO, a synergist for residential pyrethroid insecticides) remains to be elucidated. We hypothesized that prenatal and age 5–6year measures of PBO and permethrins would be associated with cough at age 5–6years in this cohort. Further, we explored the associations between these pesticide measures and wheeze, asthma, seroatopy, and fractional exhaled nitric oxide (FeNO). PBO and permethrins were measured in personal air during the third trimester of pregnancy and indoor residential air at age 5–6years (n=224). Health outcome questionnaires were administered to the mothers of 5–6year old children. Indoor allergen specific and total immunoglobulin (Ig) E production was measured from sera collected at age 5, and FeNO was measured at 5–6years. The hypotheses were tested using regression models adjusting for common confounders. Noninfectious cough was reported among 14% of children at age 5–6years. Measures of prenatal PBO, but not age 5–6year PBO or permethrins, increased the odds of cough [OR (95% CI): 1.27 (1.09–1.48), p
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2012.07.009