Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove

Mutations in ATP13A2 (PARK9) cause an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia called Kufor-Rakeb Syndrome (KRS). The ATP13A2 gene encodes a transmembrane lysosomal P5-type ATPase (ATP13A2) whose physiological function in mammalian cells, and henc...

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Bibliographic Details
Published in:Autophagy 2012-09, Vol.8 (9), p.1389-1391
Main Authors: Dehay, Benjamin, Martinez-Vicente, Marta, Ramirez, Alfredo, Perier, Celine, Klein, Christine, Vila, Miquel, Bezard, Erwan
Format: Article
Language:English
Subjects:
ATP13A2
Autophagic Punctum
Autophagy
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Dopaminergic Neurons - metabolism
Dopaminergic Neurons - pathology
Humans
Landes
Lewy Bodies - metabolism
Life Sciences
lysosome
Lysosomes - metabolism
Lysosomes - pathology
neurodegeneration
Organogenesis
Parkinson disease
Parkinson Disease - genetics
Parkinson Disease - physiopathology
Proteins
Proton-Translocating ATPases - deficiency
Proton-Translocating ATPases - genetics
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Summary:Mutations in ATP13A2 (PARK9) cause an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia called Kufor-Rakeb Syndrome (KRS). The ATP13A2 gene encodes a transmembrane lysosomal P5-type ATPase (ATP13A2) whose physiological function in mammalian cells, and hence its potential role in Parkinson disease (PD), remains elusive. In this context, we have recently shown that KRS-linked mutations in ATP13A2 leads to several lysosomal alterations in ATP13A2 KRS patient-derived fibroblasts, including impaired lysosomal acidification, decreased proteolytic processing of lysosomal enzymes, reduced degradation of lysosomal substrates and diminished lysosomal-mediated clearance of autophagosomes (AP). Similar alterations are observed in stable ATP13A2-knockdown dopaminergic cell lines, which are associated with cell death. Restoration of ATP13A2 levels in ATP13A2-mutant/depleted cells is able to restore lysosomal function and attenuate cell death. Relevant to PD, we have determined that ATP13A2 levels are decreased in dopaminergic nigral neurons from sporadic PD patients. Interestingly in these patients, the main signal of ATP13A2 is detected in the Lewy bodies. Our results unravel an instrumental role of ATP13A2 in lysosomal function and in cell viability. Altogether, our results validate ATP13A2 as a likely therapeutic target against PD degeneration.
ISSN:1554-8627
1554-8635
DOI:10.4161/auto.21011