Magnetic Resonance-Based Imaging in Animal Models of Fetal Alcohol Spectrum Disorder

Magnetic resonance imaging (MRI) techniques, such as magnetic resonance microscopy (MRM), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS), have recently been applied to the study of both normal and abnormal structure and neurochemistry in small animals. Herein, findings fro...

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Bibliographic Details
Published in:Neuropsychology review 2011-06, Vol.21 (2), p.167-185
Main Authors: O’Leary-Moore, Shonagh K., Parnell, Scott E., Lipinski, Robert J., Sulik, Kathleen K.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Brain - embryology
Brain - growth & development
Brain - pathology
Brain Mapping
Developmental Disabilities - etiology
Developmental Disabilities - pathology
Diagnostic Imaging - classification
Diagnostic Imaging - methods
Disease Models, Animal
Embryos
Ethanol
Ethanol - toxicity
Facial Asymmetry - etiology
Facial Asymmetry - pathology
Female
Fetal Alcohol Spectrum Disorders - diagnosis
Fetal Alcohol Spectrum Disorders - etiology
Fetal alcohol syndrome
Fetuses
Imaging, Three-Dimensional
Magnetic resonance imaging
Male
Mice
Microcephaly
Microscopy
Nervous system
Neurochemistry
Neurology
Neuropsychology
Neurosciences
Nose
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
Review
Spectrum analysis
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Summary:Magnetic resonance imaging (MRI) techniques, such as magnetic resonance microscopy (MRM), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS), have recently been applied to the study of both normal and abnormal structure and neurochemistry in small animals. Herein, findings from studies in which these methods have been used for the examination of animal models of Fetal Alcohol Spectrum Disorder (FASD) are discussed. Emphasis is placed on results of imaging studies in fetal and postnatal mice that have highlighted the developmental stage dependency of prenatal ethanol exposure-induced CNS defects. Consideration is also given to the promise of methodological advances to allow in vivo studies of aberrant brain and behavior relationships in model animals and to the translational nature of this work.
ISSN:1040-7308
1573-6660
DOI:10.1007/s11065-011-9164-z