Phencyclidine/schizophrenia: one view toward the past, the other to the future

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ke...

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Bibliographic Details
Published in:Schizophrenia bulletin 2012-09, Vol.38 (5), p.914-919
Main Authors: Domino, Edward F, Luby, Elliot D
Format: Article
Language:English
Subjects:
Anesthetics - history
Animals
Disease Models, Animal
History, 20th Century
History, 21st Century
Humans
Invited Themed
Neuropharmacology - history
Phencyclidine - history
Psychoses, Substance-Induced - history
Schizophrenia - history
Street Drugs - history
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Summary:The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbs011