Genetic architecture of body size in mammals

Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

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Bibliographic Details
Published in:Genome biology 2012-01, Vol.13 (4), p.244-244
Main Authors: Kemper, Kathryn E, Visscher, Peter M, Goddard, Michael E
Format: Article
Language:English
Subjects:
Alleles
Animals
body size
Body Size - genetics
Body Size - physiology
Genetic Association Studies - methods
Genetic Loci
Genetic Pleiotropy
heritability
Humans
Linkage Disequilibrium
mammals
Mammals - genetics
Mammals - physiology
Mice
Mice, Knockout
Mutation
Mutation Rate
Pedigree
pleiotropy
Polymorphism, Genetic
Review
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Description
Summary:Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.
ISSN:1465-6906
1465-6914
1474-760X
DOI:10.1186/gb-2012-13-4-244