Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans

All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive respo...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Zhao, Y.-L., Wang, D.-Y.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Antioxidants - metabolism
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - metabolism
Environmental Pollutants - toxicity
Glutathione - metabolism
Heat-Shock Proteins - metabolism
Metallothionein - metabolism
Oxidative Stress - drug effects
Review
RNA Interference
Signal Transduction
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Summary:All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress. The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor. In C. elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction. Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation. In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses. In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C. elegans and discussed some possible alternative theories explaining the adaptive response control.
ISSN:1942-0900
1942-0994
DOI:10.1155/2012/564093