Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

Abstract In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was obse...

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Bibliographic Details
Published in:Leukemia research 2012-11, Vol.36 (11), p.1359-1364
Main Authors: D’Amelio, Anthony M, Monroy, Claudia, El-Zein, Randa, Etzel, Carol J
Format: Article
Language:English
Subjects:
DNA repair
DNA-Binding Proteins - genetics
Female
Genetic Predisposition to Disease - genetics
Haplotypes
Hematology, Oncology and Palliative Medicine
Hodgkin Disease - genetics
Hodgkin lymphoma
Humans
Inflammation
Interleukin-4 Receptor alpha Subunit - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Single nucleotide polymorphism
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Summary:Abstract In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2012.07.014