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Lack of association between five serotonin metabolism-related genes and medication overuse headache
Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some...
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| Published in: | Journal of headache and pain 2010-02, Vol.11 (1), p.53-58 |
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| container_end_page | 58 |
| container_issue | 1 |
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| container_title | Journal of headache and pain |
| container_volume | 11 |
| creator | Cevoli, Sabina Marzocchi, Nadia Capellari, Sabina Scapoli, Chiara Pierangeli, Giulia Grimaldi, Daniela Naldi, Federica Alberto Pini, L. Montagna, Pasquale Cortelli, Pietro |
| description | Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (
5HTT
), serotonin receptor 1A (
5-HT1A
), serotonin receptor 1B (
5-HT1B
), serotonin receptor 2A (
5-HT2A
) and serotonin receptor 6 (
5HT6
) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the
5HTT
,
5-HT1A
,
5HT1B
,
5HT2A
and
5HT6
gene polymorphisms play a role in the genetic predisposition to MOH. |
| doi_str_mv | 10.1007/s10194-009-0168-5 |
| format | article |
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5HTT
), serotonin receptor 1A (
5-HT1A
), serotonin receptor 1B (
5-HT1B
), serotonin receptor 2A (
5-HT2A
) and serotonin receptor 6 (
5HT6
) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the
5HTT
,
5-HT1A
,
5HT1B
,
5HT2A
and
5HT6
gene polymorphisms play a role in the genetic predisposition to MOH.</description><identifier>ISSN: 1129-2369</identifier><identifier>EISSN: 1129-2377</identifier><identifier>DOI: 10.1007/s10194-009-0168-5</identifier><identifier>PMID: 19936617</identifier><identifier>CODEN: JHPOAT</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chronic illnesses ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Drug therapy ; Female ; Gene Frequency ; Genes ; Genetic Association Studies ; Genetic Predisposition to Disease - genetics ; Genotype ; Headache Disorders, Secondary - genetics ; Headaches ; Humans ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Minisatellite Repeats - genetics ; Neurology ; Neurotransmitters ; Original ; Pain Medicine ; Polymorphism ; Polymorphism, Genetic - genetics ; Receptors, Serotonin - genetics ; Serotonin - genetics ; Serotonin - metabolism ; Serotonin Plasma Membrane Transport Proteins - genetics ; Vascular diseases and vascular malformations of the nervous system ; Young Adult</subject><ispartof>Journal of headache and pain, 2010-02, Vol.11 (1), p.53-58</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-af1ac295dfabbfff3d9c0b1e0c579889a0355365c6e4c8858a25e791abb7b4ae3</citedby><cites>FETCH-LOGICAL-c564t-af1ac295dfabbfff3d9c0b1e0c579889a0355365c6e4c8858a25e791abb7b4ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/204089166/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/204089166?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22806742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19936617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cevoli, Sabina</creatorcontrib><creatorcontrib>Marzocchi, Nadia</creatorcontrib><creatorcontrib>Capellari, Sabina</creatorcontrib><creatorcontrib>Scapoli, Chiara</creatorcontrib><creatorcontrib>Pierangeli, Giulia</creatorcontrib><creatorcontrib>Grimaldi, Daniela</creatorcontrib><creatorcontrib>Naldi, Federica</creatorcontrib><creatorcontrib>Alberto Pini, L.</creatorcontrib><creatorcontrib>Montagna, Pasquale</creatorcontrib><creatorcontrib>Cortelli, Pietro</creatorcontrib><title>Lack of association between five serotonin metabolism-related genes and medication overuse headache</title><title>Journal of headache and pain</title><addtitle>J Headache Pain</addtitle><addtitle>J Headache Pain</addtitle><description>Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (
5HTT
), serotonin receptor 1A (
5-HT1A
), serotonin receptor 1B (
5-HT1B
), serotonin receptor 2A (
5-HT2A
) and serotonin receptor 6 (
5HT6
) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the
5HTT
,
5-HT1A
,
5HT1B
,
5HT2A
and
5HT6
gene polymorphisms play a role in the genetic predisposition to MOH.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chronic illnesses</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Headache Disorders, Secondary - genetics</subject><subject>Headaches</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats - genetics</subject><subject>Neurology</subject><subject>Neurotransmitters</subject><subject>Original</subject><subject>Pain Medicine</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Receptors, Serotonin - genetics</subject><subject>Serotonin - genetics</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Young Adult</subject><issn>1129-2369</issn><issn>1129-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kUuLFDEUhQtRnIf-ADdSCDKr0jwqr40wDL6gwY2uw63UTXfG6mRMqlr892aopkcFV7lwv3NyLqdpXlDyhhKi3hZKqOk7QkxHqNSdeNScU8pMx7hSj0-zNGfNRSm3hDDCtXjanFFjuJRUnTduA-57m3wLpSQXYA4ptgPOPxFj68MB24I5zSmG2O5xhiFNoey7jBPMOLZbjFhaiGNdjsGt8nTAvBRsdwgjuB0-a554mAo-P76XzbcP77_efOo2Xz5-vrnedE7Ifu7AU3DMiNHDMHjv-WgcGSgSJ5TR2gDhQnApnMTeaS00MIHK0EqroQfkl8271fduGWoch3HOMNm7HPaQf9kEwf69iWFnt-lgeS8Y1aYaXB0NcvqxYJntPhSH0wQR01Ks4lwTxSmv5Kt_yNu05Fivs4z0RBsqZYXoCrmcSsnoT1EosfcF2rVAWwu09wVaUTUv_7zhQXFsrAKvjwAUB5PPEF0oJ44xTaTqWeXYypW6ilvMDwn___tvmGu12g</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Cevoli, Sabina</creator><creator>Marzocchi, Nadia</creator><creator>Capellari, Sabina</creator><creator>Scapoli, Chiara</creator><creator>Pierangeli, Giulia</creator><creator>Grimaldi, Daniela</creator><creator>Naldi, Federica</creator><creator>Alberto Pini, L.</creator><creator>Montagna, Pasquale</creator><creator>Cortelli, Pietro</creator><general>Springer Milan</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Lack of association between five serotonin metabolism-related genes and medication overuse headache</title><author>Cevoli, Sabina ; Marzocchi, Nadia ; Capellari, Sabina ; Scapoli, Chiara ; Pierangeli, Giulia ; Grimaldi, Daniela ; Naldi, Federica ; Alberto Pini, L. ; Montagna, Pasquale ; Cortelli, Pietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-af1ac295dfabbfff3d9c0b1e0c579889a0355365c6e4c8858a25e791abb7b4ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chronic illnesses</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Headache Disorders, Secondary - genetics</topic><topic>Headaches</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats - genetics</topic><topic>Neurology</topic><topic>Neurotransmitters</topic><topic>Original</topic><topic>Pain Medicine</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Receptors, Serotonin - genetics</topic><topic>Serotonin - genetics</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cevoli, Sabina</creatorcontrib><creatorcontrib>Marzocchi, Nadia</creatorcontrib><creatorcontrib>Capellari, Sabina</creatorcontrib><creatorcontrib>Scapoli, Chiara</creatorcontrib><creatorcontrib>Pierangeli, Giulia</creatorcontrib><creatorcontrib>Grimaldi, Daniela</creatorcontrib><creatorcontrib>Naldi, Federica</creatorcontrib><creatorcontrib>Alberto Pini, L.</creatorcontrib><creatorcontrib>Montagna, Pasquale</creatorcontrib><creatorcontrib>Cortelli, Pietro</creatorcontrib><collection>Springer_OA刊</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of headache and pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cevoli, Sabina</au><au>Marzocchi, Nadia</au><au>Capellari, Sabina</au><au>Scapoli, Chiara</au><au>Pierangeli, Giulia</au><au>Grimaldi, Daniela</au><au>Naldi, Federica</au><au>Alberto Pini, L.</au><au>Montagna, Pasquale</au><au>Cortelli, Pietro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association between five serotonin metabolism-related genes and medication overuse headache</atitle><jtitle>Journal of headache and pain</jtitle><stitle>J Headache Pain</stitle><addtitle>J Headache Pain</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>11</volume><issue>1</issue><spage>53</spage><epage>58</epage><pages>53-58</pages><issn>1129-2369</issn><eissn>1129-2377</eissn><coden>JHPOAT</coden><abstract>Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (
5HTT
), serotonin receptor 1A (
5-HT1A
), serotonin receptor 1B (
5-HT1B
), serotonin receptor 2A (
5-HT2A
) and serotonin receptor 6 (
5HT6
) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the
5HTT
,
5-HT1A
,
5HT1B
,
5HT2A
and
5HT6
gene polymorphisms play a role in the genetic predisposition to MOH.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>19936617</pmid><doi>10.1007/s10194-009-0168-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of headache and pain, 2010-02, Vol.11 (1), p.53-58 |
| issn | 1129-2369 1129-2377 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3452189 |
| source | NCBI_PubMed Central（免费）; Publicly Available Content Database; Springer Nature - SpringerLink Journals - Fully Open Access |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Chronic illnesses Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug therapy Female Gene Frequency Genes Genetic Association Studies Genetic Predisposition to Disease - genetics Genotype Headache Disorders, Secondary - genetics Headaches Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Minisatellite Repeats - genetics Neurology Neurotransmitters Original Pain Medicine Polymorphism Polymorphism, Genetic - genetics Receptors, Serotonin - genetics Serotonin - genetics Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Vascular diseases and vascular malformations of the nervous system Young Adult |
| title | Lack of association between five serotonin metabolism-related genes and medication overuse headache |
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