Circulating thrombotic and haemostatic components in patients with coronary artery disease

The study aimed to analyze the circulating levels of thrombotic and haemostatic components; tissue factor, tissue factor pathway inhibitor, tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with acute myocardial infarction at presentation (Group 1, n=49), unstable angina...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2010, Vol.25 (1), p.20-28
Main Authors: Shalia, Kavita K., Shah, V. K., Mashru, M. R., Soneji, S. L., Vasvani, J. B., Payannavar, S. S., Walvalkar, A. P., Mokal, R. A., Mithbawkar, S. M., Kudalkar, K. V., Abraham, A., Thakur, P. K.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Blood clots
Cardiovascular disease
Chemistry/Food Science
Circulatory system
Life Sciences
Microbiology
Original
Original Article
Pathology
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Summary:The study aimed to analyze the circulating levels of thrombotic and haemostatic components; tissue factor, tissue factor pathway inhibitor, tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with acute myocardial infarction at presentation (Group 1, n=49), unstable angina and Non-ST elevated MI after treatment (Group 2, n=22), stable angina (Group 3, n=18) and healthy individuals (Group 4, n=31). Significant finding was increase in tissue factor not only in Group 1 (2.0 fold, P=0.001), Group 2 (2.2 fold, P=0.015) but also in Group 3 (1.8 fold, P=0.018) as compared to controls. In Group 1 Plasminogen activator inhibitor-1 increased significantly (35.8%, P=0.02). Tissue factor pathway inhibitor and tissue plasminogen activator demonstrated increase in Group 1 of age
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-010-0005-2