Copper and ceruloplasmin levels in relation to total thiols and GST in type 2 diabetes mellitus patients

Presence of oxidative stress in type 2 diabetes mellitus (DM) is well proved. Current study was undertaken to know the relation between fasting plasma glucose (FPG) and copper along with antioxidants like total thiols and ceruloplasmin, and antioxidant enzyme glutathione S transferase (GST). The stu...

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Published in:Indian journal of clinical biochemistry 2010, Vol.25 (1), p.74-76
Main Authors: Sarkar, A., Dash, S., Barik, B. K., Muttigi, Manjunatha S., Kedage, V., Shetty, J. K., Prakash, M.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Copper
Diabetes
Enzymes
Life Sciences
Microbiology
Original
Original Article
Oxidation
Pathology
Proteins
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Summary:Presence of oxidative stress in type 2 diabetes mellitus (DM) is well proved. Current study was undertaken to know the relation between fasting plasma glucose (FPG) and copper along with antioxidants like total thiols and ceruloplasmin, and antioxidant enzyme glutathione S transferase (GST). The study group consisted of a total of 201 subjects which included nondiabetic healthy control subjects (n = 78) and diabetic patients (n = 123). Plasma total thiols, GST, copper and ceruloplasmin levels were measured all the subjects using spectrophotometric methods and FPG levels were determined in clinical chemistry analyzer Hitachi 912. There was significant increase in FPG (P
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-010-0015-0