Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats

The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of serum glutamate pyruvate transaminase (SGPT), serum...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2009-10, Vol.24 (4), p.414-418
Main Authors: Sharmila Banu, G., Kumar, G., Murugesan, A. G.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Herbal medicine
Life Sciences
Liver diseases
Microbiology
Original
Original Article
Pathology
Rodents
Toxins
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Summary:The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), and total bilirubin, which indicated acute hepatocellular damage and biliary obstruction. Ethanolic leaf extract of T. portulacastrum showed dose dependent decrease in the levels of SGPT, SGOT, ALP and total bilirubin. Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity against aflatoxin-induced hepatotoxicity. Thus the study demonstrates that T. portulacastrum possess antihepatotoxic effect against aflatoxin.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-009-0074-2