Free radical injury and antioxidant status in patients with benign prostate hyperplasia and prostate cancer

Reactive oxygen species and other free radicals are known to be the mediators of phenotypic and genotypic changes that lead from mutation to neoplasia. There are some primary antioxidants such as glutathione peroxidase (GPx), glutathione S-transferases (GSTs) and reduced glutathione, which protect a...

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Published in:Indian journal of clinical biochemistry 2005-07, Vol.20 (2), p.162-165
Main Authors: Srivastava, D S L, Mittal, R D
Format: Article
Language:English
Subjects:
Antioxidants
Free radicals
Genital diseases
Glutathione peroxidase
Hydrogen peroxide
Hyperplasia
Lipid peroxidation
Metabolites
Oxidants
Prostate cancer
Reactive oxygen species
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description Reactive oxygen species and other free radicals are known to be the mediators of phenotypic and genotypic changes that lead from mutation to neoplasia. There are some primary antioxidants such as glutathione peroxidase (GPx), glutathione S-transferases (GSTs) and reduced glutathione, which protect against callular and molecular damage caused by the reactive oxygen metabolites (ROMs). The present study was conducted to determine the level of malondialdehyde (MDA), as an index of lipid peroxidation, along with the GPx, GSTs activities and level of reduced glutathione in 45 prostate cancer (PC) patients, 55 benign prostate hyperplasia (BPH) patients as compared to the controls. Significant higher levels of MDA and GSTs activities in the serum, (P
doi_str_mv 10.1007/BF02867419
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The higher MDA and lower GPx activities may be inadequate to detoxify high levels of H(2)O(2) into H(2)O leading to the formation of the(*)OH radical followed by MDA. 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subjects Antioxidants
Free radicals
Genital diseases
Glutathione peroxidase
Hydrogen peroxide
Hyperplasia
Lipid peroxidation
Metabolites
Oxidants
Prostate cancer
Reactive oxygen species
title Free radical injury and antioxidant status in patients with benign prostate hyperplasia and prostate cancer
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