The ubiquitin-proteasome system of Saccharomyces cerevisiae

Protein modifications provide cells with exquisite temporal and spatial control of protein function. Ubiquitin is among the most important modifiers, serving both to target hundreds of proteins for rapid degradation by the proteasome, and as a dynamic signaling agent that regulates the function of c...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 2012-10, Vol.192 (2), p.319-360
Main Authors: Finley, Daniel, Ulrich, Helle D, Sommer, Thomas, Kaiser, Peter
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cellular biology
Genomics
Membrane Proteins - genetics
Membrane Proteins - metabolism
Proteasome Endopeptidase Complex - genetics
Proteasome Endopeptidase Complex - ultrastructure
Protein Processing, Post-Translational - genetics
Protein Transport
Proteins
Proteolysis
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins
Substrate Specificity
Ubiquitin - genetics
Ubiquitin - physiology
Ubiquitination - genetics
Valosin Containing Protein
Yeast
YeastBook
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Protein modifications provide cells with exquisite temporal and spatial control of protein function. Ubiquitin is among the most important modifiers, serving both to target hundreds of proteins for rapid degradation by the proteasome, and as a dynamic signaling agent that regulates the function of covalently bound proteins. The diverse effects of ubiquitylation reflect the assembly of structurally distinct ubiquitin chains on target proteins. The resulting ubiquitin code is interpreted by an extensive family of ubiquitin receptors. Here we review the components of this regulatory network and its effects throughout the cell.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.112.140467