A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility

To compare outcomes in patients with unexplained infertility undergoing conventional in vitro fertilization (IVF) versus intracytoplasmic sperm injection (ICSI). Sixty women with unexplained infertility in a Canadian tertiary-level clinic were randomized to IVF or ICSI. Subjects underwent downregula...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2006-03, Vol.23 (3), p.137-140
Main Authors: Foong, Shu C, Fleetham, Judy A, O'Keane, Joseph A, Scott, Selma G, Tough, Suzanne C, Greene, Calvin A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Canada
Down-Regulation
Female
Fertilization in Vitro - methods
Follicle Stimulating Hormone - therapeutic use
Gonadotropin-Releasing Hormone - therapeutic use
Humans
Infertility - therapy
Oocytes - metabolism
Pregnancy
Pregnancy Rate
Short Communication
Sperm Injections, Intracytoplasmic - methods
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Summary:To compare outcomes in patients with unexplained infertility undergoing conventional in vitro fertilization (IVF) versus intracytoplasmic sperm injection (ICSI). Sixty women with unexplained infertility in a Canadian tertiary-level clinic were randomized to IVF or ICSI. Subjects underwent downregulation with gonadotropin-releasing hormone agonist prior to initiation of recombinant human follicle-stimulating hormone. The primary outcome measure was fertilization rate. Secondary outcomes included implantation rate, embryo quality, clinical pregnancy rate, and live birth rate. There was no statistically significant difference in fertilization rate (77.2% IVF vs. 82.4% ICSI), implantation rate (38.2% IVF vs. 44.4% ICSI), clinical pregnancy rate (50% in each group), or live birth rate (46.7% IVF vs. 50% ICSI). There were two cases of failed fertilization in the IVF group. There was no significant difference in embryo quality between groups. There were no differences in clinical outcomes associated with IVF versus ICSI in the treatment of unexplained infertility.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-005-9008-y