Structural sperm and aneuploidies studies in a case of spermatogenesis recovery after the use of androgenic anabolic steroids

Azoospermia may sometimes be related to the use of androgenic anabolic steroids. We report the case of an azoospermic man who had abused androgenic anabolic steroids and who recovered spermatogenesis six months after cessation of abuse and the administration of hormonal therapy. An azoospermic 34-ye...

Full description

Saved in:
Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2007-05, Vol.24 (5), p.195-198
Main Authors: Moretti, E, Collodel, G, La Marca, A, Piomboni, P, Scapigliati, G, Baccetti, B
Format: Article
Language:English
Subjects:
Abuse
Adult
Anabolic Agents - adverse effects
Anabolic steroids
Androgens - adverse effects
Azoospermia - etiology
Case Report
Hormones - blood
Humans
Hybridization
Infertility
Infertility, Male - chemically induced
Male
Meiosis
Sperm
Spermatogenesis
Spermatogenesis - drug effects
Spermatogenesis - physiology
Spermatozoa - cytology
Spermatozoa - drug effects
Spermatozoa - ultrastructure
Steroid hormones
Transmission electron microscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Azoospermia may sometimes be related to the use of androgenic anabolic steroids. We report the case of an azoospermic man who had abused androgenic anabolic steroids and who recovered spermatogenesis six months after cessation of abuse and the administration of hormonal therapy. An azoospermic 34-year-old man came to Regional Referral Center for Male Infertility. The recovery of spermatogenesis was observed after the cessation of abuse of steroids and the administration of hormonal therapy. Ultrastructural analysis of sperm was carried out by transmission electron microscopy, and the meiotic segregation of chromosomes 1, 9, 18, X, Y was investigated. Mathematically elaborated transmission electron microscopy data highlighted seminal features close to normal fertility. Fluorescence in situ hybridisation showed a high frequency of XY disomy in sperm. Our findings confirm the recovery of spermatogenesis but suggest a possible relationship between altered meiotic segregation and the abuse of androgenic anabolic steroids.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-005-9002-4