Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation

To investigate the effect of the cumulative exposure to estradiol (E(2)) during the follicular phase on IVF outcome. Patients were stimulated with recombinant FSH after GnRH agonist suppression and had a day 3-embryo transfer. Estrogen exposure was determined as the area under the curve (AUC) for se...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2007-04, Vol.24 (4), p.111-117
Main Authors: Arslan, Murat, Bocca, Silvina, Arslan, Ebru Ozturk, Duran, Hakan E, Stadtmauer, Laurel, Oehninger, Sergio
Format: Article
Language:English
Subjects:
17β-Estradiol
Adult
Chorionic Gonadotropin - blood
Embryo Implantation - drug effects
Embryo Transfer
Embryos
Estradiol - pharmacology
Estrogens
Female
Fertilization
Fertilization in Vitro
Follicle-stimulating hormone
Follicular Phase - drug effects
Follicular Phase - physiology
Gonadotropin-releasing hormone
Gynecology
Humans
Implantation
Obstetrics
Oocytes
Original Paper
Ovaries
Ovulation
Ovulation Induction - methods
Pregnancy
Retrospective Studies
Steroids
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Summary:To investigate the effect of the cumulative exposure to estradiol (E(2)) during the follicular phase on IVF outcome. Patients were stimulated with recombinant FSH after GnRH agonist suppression and had a day 3-embryo transfer. Estrogen exposure was determined as the area under the curve (AUC) for serum E(2) levels measured from the first day of stimulation through the day after hCG administration. E(2) AUC thresholds for 10th and 90th percentiles were 4704 pg/ml and 16338 pg/ml, respectively. The pregnancy and implantation rates were highest in the 10th-90th percentile group, and were statistically higher in this group than in the >90th percentile group (54.6% vs. 33.3% and 24.8% and 12.9%, respectively, for pregnancy and implantation rates, P < 0.05). Recovered mature oocytes, fertilization, and number and mean score of transferred embryos were similar. High cumulative E(2) exposure during the follicular phase of IVF cycles has detrimental effects on implantation.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-006-9101-x