Does previous response to clomifene citrate influence the selection of gonadotropin dosage given in subsequent superovulation treatment cycles?

• Published in: Journal of assisted reproduction and genetics 2006-12, Vol.23 (11-12), p.427-431
• Main Authors: Nguyen, Tien Huu, Lennard, Martin S, Ghobadi, Cyrus, Rostami-Hodjegan, Amin, Ledger, William L
• Format: Article
• Language: English
• Subjects: Anovulation; Clomiphene - therapeutic use; Dose-Response Relationship, Drug; Estradiol - blood; Female; Fertility Agents, Female - therapeutic use; Fertilization in Vitro - methods; Gonadotropins - therapeutic use; Humans; In vitro fertilization; Infertility; Original Paper; Ovaries; Ovulation; Ovulation - drug effects; Patient Selection; Patients; Superovulation; Ultrasonic imaging
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-006-9065-x

To determine whether ovarian response to previous clomifene treatment could influence the selection of the starting dose of gonadotropins in subsequent in vitro fertilization (IVF) or intra uterine insemination (IUI). Forty three anovular women who had received clomifene for ovulation induction followed by gonadotropins for IUI or IVF superovulation were reviewed retrospectively. Data on gonadotropin dose were compared between clomifene-resistant patients and clomifene responders. IVF patients who had had prior superovulation/IUI treatment received similar doses of gonadotropins regardless of response to clomifene (1610 IU versus 1560 IU, p = 0.74). In IVF patients not receiving prior IUI treatment, the clomifene-resistant women were given higher doses of gonadotropins than those responding to clomifene (2500 IU versus 1440 IU, p = 0.042). We found that, in our Unit, clinicians appeared to use prior non-response to clomifene as a reason for prescribing a higher starting dose of gonadotropins in IVF treatment, a practice that is not evidence-based.