Effect of pentoxifylline on immotile testicular spermatozoa

A model for differentiating live and dead sperm cells during intracytoplasmic sperm injection (ICSI) is proposed. We used pentoxifylline, a phosphodiesterase inhibitor known to enhance sperm motility, to initiate motility in testicular spermatozoa. Ten immotile testicular sperm samples were divided...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 1998, Vol.15 (2), p.90-92
Main Authors: TASDEMIR, I, TASDEMIR, M, TAVUKCUOGLU, S
Format: Article
Language:English
Subjects:
Analysis of Variance
Andrology
Biological and medical sciences
Birth control
Cell differentiation
Fertilization
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Pentoxifylline - pharmacology
Phosphodiesterase inhibitors
Phosphodiesterase Inhibitors - pharmacology
Sperm
Sperm Motility - drug effects
Sperm Motility - physiology
Spermatozoa - drug effects
Spermatozoa - physiology
Sterility. Assisted procreation
Testes
Testis - cytology
Testis - physiology
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Summary:A model for differentiating live and dead sperm cells during intracytoplasmic sperm injection (ICSI) is proposed. We used pentoxifylline, a phosphodiesterase inhibitor known to enhance sperm motility, to initiate motility in testicular spermatozoa. Ten immotile testicular sperm samples were divided into two parts for examination of sperm motility with and without pentoxifylline treatment at 30, 60, and 90 min. The samples without pentoxifylline remained immotile even after 90 min of incubation: the addition of pentoxifylline initiated sperm motility in all samples: 51.8 +/- 10.2, 64.4 +/- 9.4, and 70.8 +/- 8.9% (mean +/- SD) at 30, 60, and 90 min, respectively. That pentoxifylline may be used to differentiate live testicular spermatozoa during ICSI, which may improve fertilization and pregnancy rates, is suggested.
ISSN:1058-0468
1573-7330
DOI:10.1007/bf02766832