Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study

To investigate the effects of short-term low-dose aspirin and/or steroid use on implantation and pregnancy rates in nonselected intracytoplasmic sperm injection (ICSI) cycles. Two-hundred patients undergoing ICSI for their first cycle were enrolled in this study. Participants were then randomized in...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2006-01, Vol.23 (1), p.15-21
Main Authors: Duvan, Candan Iltemir, Ozmen, Batuhan, Satiroglu, Hakan, Atabekoglu, Cem Somer, Berker, Bulent
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Aspirin
Aspirin - administration & dosage
Dose-Response Relationship, Drug
Drug dosages
Embryo Implantation - drug effects
Embryos
Female
Gynecology
Humans
Immunosuppressive agents
In vitro fertilization
Laboratories
Medicine
Obstetrics
Original Paper
Ovulation
Prednisolone - administration & dosage
Pregnancy
Pregnancy Rate
Prospective Studies
Sperm
Sperm Injections, Intracytoplasmic
Steroids
Success
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Summary:To investigate the effects of short-term low-dose aspirin and/or steroid use on implantation and pregnancy rates in nonselected intracytoplasmic sperm injection (ICSI) cycles. Two-hundred patients undergoing ICSI for their first cycle were enrolled in this study. Participants were then randomized into four groups on the embryo transfer day. Aspirin (100 mg/day) in group A, prednisolone (10 mg/day) in group B, aspirin along with prednisolone in group C were given while placebo was administrated to group D. There were no statistically significant differences recorded in the demographic, ovulation induction cycle characteristics between groups. Mean transferred embryo number and mean top quality embryo number were similar among study groups. There were no statistical differences in implantation and pregnancy rates between study groups. Administration of low-dose aspirin and prednisolone alone or concomitant as a standard treatment have no positive effects on implantation and/or pregnancy rates.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-005-9003-3