Multiple autoantibodies associated with autoimmune reproductive failure

Autoimmune factors are involved in some of the cases of reproductive failure. The aim of this paper is to discuss the association between autoantibodies and reproductive failure. Literature review of autoantibodies associated with reproductive failure. Several autoantibodies were found in associatio...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2003-02, Vol.20 (2), p.53-57
Main Authors: SHERER, Yaniv, TARTAKOVER-MATALON, Shelly, BLANK, Miri, MATSUURA, Eiji, SHOENFELD, Yehuda
Format: Article
Language:English
Subjects:
Abortion, Habitual - immunology
Anemia
Animals
Antibodies
Autoantibodies - adverse effects
Autoantibodies - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Biological and medical sciences
Female
Female genital diseases
Glycoproteins
Gynecology. Andrology. Obstetrics
Humans
Lupus
Medical sciences
Miscarriage
Non tumoral diseases
Obstetrics
Pregnancy
Thrombocytopenia
Thrombosis
Thyroid gland
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Summary:Autoimmune factors are involved in some of the cases of reproductive failure. The aim of this paper is to discuss the association between autoantibodies and reproductive failure. Literature review of autoantibodies associated with reproductive failure. Several autoantibodies were found in association with such clinical manifestations, mainly in patients having systemic lupus erythematosus or the antiphospholipid syndrome. These autoantibodies include "classical" antiphospholipid antibodies such as anticardiolipin, anti-beta2-glycoprotein-I, antiphosphatidylserine, and antiphosphatidylethanolamine. There are also some "nonclassical" antiphospholipid antibodies directed to prothrombin, thromboplastin, or mitochondrial antibodies of M5 type, which were also found in patients with reproductive failure. Moreover, animal models as well as some human studies support a role for other autoantibodies in these clinical manifestations including antihyroglobulin, antilaminin-1, anti-corpus luteum, antiprolactin, anti-poly(ADP-ribose), and lymphocytotoxic antibodies. Even though there is not enough data currently to support a firm association between some of these autoantibodies and reproductive failure, future studies are likely to help us determine and expand the number of autoantibodies screened in these patients.
ISSN:1058-0468
1573-7330
DOI:10.1023/A:1021716623305