Variable expression of Oviductin mRNA at different stages of human reproductive cycle

To examine the in vivo expression of oviductin mRNA at different stages of the human female reproductive cycle including pregnancy and after menopause. Oviducts were obtained from 25 women in normal menstrual cycle, 5 in early pregnancy, 5 undergoing postpartum sterilization, and 4 menopausal women....

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2002-12, Vol.19 (12), p.569-576
Main Authors: LOK, Ingrid H, BRITON-JONES, Christine M, YUEN, Pong M, HAINES, Christopher J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Embryos
Enzymes
Estradiol - blood
Estrogens
Fallopian Tubes - metabolism
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Gene Expression
Humans
Laparoscopy
Luteinizing Hormone - blood
Mammalian female genital system
Menstrual Cycle - genetics
Menstruation
Morphology. Physiology
Ovaries
Ovulation
Postmenopause - genetics
Postpartum period
Postpartum Period - genetics
Pregnancy
Pregnancy - genetics
Progesterone - blood
Reproduction - genetics
RNA, Messenger - metabolism
Serine Endopeptidases - genetics
Sheep
Sperm
Vertebrates: reproduction
Womens health
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Summary:To examine the in vivo expression of oviductin mRNA at different stages of the human female reproductive cycle including pregnancy and after menopause. Oviducts were obtained from 25 women in normal menstrual cycle, 5 in early pregnancy, 5 undergoing postpartum sterilization, and 4 menopausal women. The oviductal mucosal tissue was isolated and oviductin mRNA was assessed using reverse-transriptase-polymerase chain reaction (RT-PCR); its correlation with various hormones was assessed. Oviductin mRNA was detected throughout the menstrual cycle, highest in the periovulatory period. It continued to be expressed in early pregnancy but was absent in the postpartum period and after menopause. The production and function of oviductin at different stages of human reproductive cycle including pregnancy is not well known. Its highest expression at the time of ovulation is consistent with a supportive role in fertilization and early embryo development.
ISSN:1058-0468
1573-7330
DOI:10.1023/A:1021263132176